ICG-carboxylic acid

ICG-carboxylic acid is near-infrared (NIR) fluorescent probe. ICG is a fluorescent dye used in medical diagnostics. ICG has absorption peaking at 800 nm and can absorb the near IR laser energy and release heat in the dyed tissue (Ex/Em = 785/810 nm) [1][2].

Product Specifications

CAS Number

[181934-09-8]

UNSPSC

12171500

Hazard Statement

H302, H315, H319, H335

Target

Fluorescent Dye

Type

Dye Reagents

Related Pathways

Others

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/icg-carboxylic-acid.html

Purity

99.85

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC1(C)C(/C=C/C=C/C=C/C=C2C(C)(C)C(C(C=CC=C3)=C3C=C4)=C4N\2CCCCCC([O-])=O)=[N+](CCCCS(=O)(O)=O)C5=C1C6=CC=CC=C6C=C5

Molecular Formula

C45H50N2O5S

Molecular Weight

730.95

Precautions

H302, H315, H319, H335

References & Citations

[1]Taylor JS, et al. Combined application of Indocyanine green (ICG) and laser lead to targeted tumor cell destruction. J Pediatr Surg. 2018;53 (12) :2475-2479.|[2]Mačianskienė R, et al. Spectral characteristics of voltage-sensitive indocyanine green fluorescence in the heart. Sci Rep. 2017;7 (1) :7983. Published 2017 Aug 11.|[3]Wu YZ, et al. From Ancient Medicine to Targeted Nanocarrier: A Sparganii Rhizoma-Derived Nanoparticle for Diagnostic Imaging and Endocrine Therapy in Cancer. ACS Appl Bio Mater. 2020 Apr 20;3 (4) :2028-2039.