AZ3146

AZ3146 is a reasonably potent Mps1 and TTK inhibitor, with IC50 of 35 nM for Mps1Cat.

Product Specifications

CAS Number

[1124329-14-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Mps1

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/AZ3146.html

Purity

99.42

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CN(CC1)CCC1OC2=CC=C(NC3=NC(N(C4CCCC4)C(N5C)=O)=C5C=N3)C(OC)=C2

Molecular Formula

C24H32N6O3

Molecular Weight

452.55

Precautions

H302, H315, H319, H335

References & Citations

[1]Hewitt L, et al. Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex. J Cell Biol. 2010 Jul 12;190 (1) :25-34.|[2]Liu X, et al. TTK activates Akt and promotes proliferation and migration of hepatocellular carcinoma cells. Oncotarget. 2015 Oct 27;6 (33) :34309-20.|[3]Gurden MD, et al. Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. Cancer Res. 2015 Aug 15;75 (16) :3340-54.