PROTAC SMARCA2 degrader-28
PROTAC SMARCA2 degrader-28 (Compound 158) is a PROTAC degrader for SMARCA2, that degrades SMARCA2 with a DC50 of 3 nM in HiBiT A549 cells. (Pink: Ligand for target protein ; Black: Linker (HY-168238) ; Blue: Ligand for E3 ligase (HY-W087383) )
Product Specifications
CAS Number
2641510-88-3
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-smarca2-degrader-28.html
Smiles
OC1=C(C2=CC(N3CC4N(C5=CC=CC(CN6CCN(C(C7CCN(C8=CC(C(N(C9CCC(NC9=O)=O)C%10=O)=O)=C%10C=C8)CC7)=O)CC6)=C5)C(CC4)C3)=C(N)N=N2)C=C(F)C=C1.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
Molecular Formula
C50H51F7N10O10
Molecular Weight
1084.99
References & Citations
[1]Duplessis M, et al., Bifunctional compounds for the treatment of cancer. WO2021083949.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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