Arecaidine but-2-ynyl ester (tosylate)
Product Specifications
UNSPSC Description
Arecaidine but-2-ynyl ester tosylate (ABET) is a selective mAChR M2 agonist that dose-dependently decreases mean arterial pressure and heart rate in rats. Arecaidine but-2-ynyl ester tosylate can be used for cardiovascular disease research[1][2]. Arecaidine but-2-ynyl ester (tosylate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Target Antigen
mAChR
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/arecaidine-but-2-ynyl-ester-tosylate.html
Purity
99.95
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CC#CCOC(C1=CCCN(C)C1)=O.O=S(O)(C2=CC=C(C)C=C2)=O
Molecular Weight
365.44
References & Citations
[1]Yoon SY, et al. A spinal muscarinic M2 receptor-GABAergic disinhibition pathway that modulates peripheral inflammation in mice. Neuropharmacology. 2007 Oct;53(5):677-86.|[2]Zhang C, et al. Role of Muscarinic Acetylcholine Receptor-2 in the Cerebellar Cortex in Cardiovascular Modulation in Anaesthetized Rats. Neurochem Res. 2016 Apr;41(4):804-12.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-107655/Arecaidine-but-2-ynyl-ester-tosylate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-107655/Arecaidine-but-2-ynyl-ester-tosylate-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
119630-77-2
Available Sizes
Curated Selection
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