PRGL493
Product Specifications
UNSPSC Description
PRGL493 is a potent and selective long-chain acyl-CoA synthetase 4 (ACSL4) inhibitor. PRGL493 blocks cell proliferation and tumor growth in both breast and prostate cellular and animal models. PRGL493 can be used for ferroptosis and tumor metastasis research[1][2].
Target Antigen
Ferroptosis
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Smiles
O=C(C)NC1=NC(C2=CN(C3=CC=CC=C3)N=C2C4=CC=C(C)O4)N5C6=C(C=CC=C6)NC5=N1
Molecular Weight
451.48
References & Citations
[1]Ana F Castillo, et al. New inhibitor targeting Acyl-CoA synthetase 4 reduces breast and prostate tumor growth, therapeutic resistance and steroidogenesis. Cell Mol Life Sci. 2021 Mar;78(6):2893-2910.|[2]Wang Y, et al. ACSL4 and polyunsaturated lipids support metastatic extravasation and colonization. Cell. 2024 Nov 19:S0092-8674(24)01270-4
Shipping Conditions
Blue Ice
CAS Number
2479378-45-3
Available Sizes
Curated Selection
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