PRGL493

Product Specifications

CAS Number

[2479378-45-3]

UNSPSC Description

PRGL493 is a potent and selective long-chain acyl-CoA synthetase 4 (ACSL4) inhibitor. PRGL493 blocks cell proliferation and tumor growth in both breast and prostate cellular and animal models. PRGL493 can be used for ferroptosis and tumor metastasis research[1][2].

Target Antigen

Ferroptosis

Type

Reference compound

Related Pathways

Apoptosis

Field of Research

Cancer

Smiles

O=C(C)NC1=NC(C2=CN(C3=CC=CC=C3)N=C2C4=CC=C(C)O4)N5C6=C(C=CC=C6)NC5=N1

Molecular Weight

451.48

References & Citations

[1]Ana F Castillo, et al. New inhibitor targeting Acyl-CoA synthetase 4 reduces breast and prostate tumor growth, therapeutic resistance and steroidogenesis. Cell Mol Life Sci. 2021 Mar;78(6):2893-2910.|[2]Wang Y, et al. ACSL4 and polyunsaturated lipids support metastatic extravasation and colonization. Cell. 2024 Nov 19:S0092-8674(24)01270-4