IMM-01

IMM-01 is a mammalian Diaphanous (mDia) -related formins agonist that inhibits DID-DAD (diaphanous inhibitory domain-diaphanous autoregulatory domain) binding with an IC50 of 140 nM. IMM-01 acts by disrupting the autoinhibitory bond between the DID and DAD domain and thus activates formins. IMM-01 shows anticancer effects[1].

Product Specifications

CAS Number

[218795-74-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Ras

Type

Reference compound

Related Pathways

Apoptosis; GPCR/G Protein; MAPK/ERK Pathway

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/imm-01.html

Purity

99.87

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

OC1=CC=C(/C=N/NC(NC(C)(C)C)=S)C(O)=C1

Molecular Formula

C12H17N3O2S

Molecular Weight

267.35

Precautions

H302, H315, H319, H335

References & Citations

[1]L Leanne Lash, et al. Small-molecule intramimics of formin autoinhibition: a new strategy to target the cytoskeletal remodeling machinery in cancer cells. Cancer Res. 2013 Nov 15;73 (22) :6793-803.