IV-255
IV-255 is a selective small molecule inhibitor of the BRG1 bromodomain. IV-255 increases the extent of DNA damage induced by Temozolomide (HY-17364) and Bleomycin (HY-108345) . IV-255 inhibits the invasiveness of GBM cells. IV-255 enhances Temozolomide-induced cell death and the apoptosis-inducing activity of Temozolomide[1].
Product Specifications
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/iv-255.html
Purity
98.41
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=CC=C(N2[C@H]3CN([C@@H](C2)C3)C(NC4=CC(F)=C(C=C4)F)=O)C=C1
Molecular Formula
C19H19F2N3O2
Molecular Weight
359.37
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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