CB2R/FAAH modulator-2

CB2R/FAAH modulator-2 (compound 26) is a dual targeting modulator that acts as a CB2R agonist and FAAH inhibitor. The Ki values for CB2R/FAAH modulator-2 are 10.8 and 152.9 nM for CB2R and CB1R, respectively, and the IC50 value for FAAH is 6.2 μM. CB2R/FAAH modulator-2 can be used in studies related to cancer, deleterious inflammatory cascades occurring in neurodegenerative diseases, and COVID-19 infection[1].

Product Specifications

CAS Number

[2876918-68-0]

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

Cannabinoid Receptor; FAAH

Type

Reference compound

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cb2r-faah-modulator-2.html

Purity

99.59

Solubility

10 mM in DMSO

Smiles

O=C(C1=C(OCC2CCCCC2)C=CC=C1)NC3(C4)C[C@H]5C[C@@H]4C[C@H](C5)C3

Molecular Formula

C24H33NO2

Molecular Weight

367.52

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Francesca Intranuovo, et al. Development of N- (1-Adamantyl) benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase. J Med Chem. 2023 Jan 12;66 (1) :235-250.