Avenanthramide A

Avenanthramide A is a phytoalexin, which can be found in oats (Avena sativa L.) . Avenanthramide A targets the RNA helicase DDX3, leads to mitochondrial swelling and increased ROS production, and induces apoptosis in CRC cells. Avenanthramide A exhibits antitumor efficacy in mouse model. Avenanthramide A orally active[1].

Product Specifications

CAS Number

[108605-70-5]

Product Name Alternative

Monobromobimane

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/avenanthramide-a.html

Purity

98.35

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC(O)=CC=C1NC(/C=C/C2=CC=C(C=C2)O)=O)O

Molecular Formula

C16H13NO5

Molecular Weight

299.28

Precautions

H302

References & Citations

[1]Fu R, et al., Avenanthramide A triggers potent ROS-mediated anti-tumor effects in colorectal cancer by directly targeting DDX3. Cell Death Dis. 2019 Aug 7;10 (8) :593.