SAR405
SAR405 is a first-in-class, selective, and ATP-competitive PI3K class III (PIK3C3) isoform Vps34 inhibitor (IC50=1.2 nM; Kd=1.5 nM) . SAR405 inhibits autophagy induced either by starvation or by mTOR inhibition. Anticancer activity[1][2].
Product Specifications
CAS Number
1523406-39-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; PI3K
Type
Reference compound
Related Pathways
Autophagy; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SAR405.html
Concentration
10mM
Purity
99.74
Solubility
DMSO : ≥ 27 mg/mL|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1N(C2=NC(N3[C@H](C)COCC3)=C1)CC[C@@H](C(F)(F)F)N2CC4=CC(Cl)=CN=C4
Molecular Formula
C19H21ClF3N5O2
Molecular Weight
443.85
Precautions
H302, H315, H319, H335
References & Citations
[1]Ronan B, et al. A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy. Nat Chem Biol. 2014 Dec;10 (12) :1013-9.|[2]Pasquier B. SAR405, a PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with MTOR inhibition in tumor cells. Autophagy. 2015 Apr 3;11 (4) :725-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Vps34
Available Sizes
Frequently Asked Questions
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