SAR405

SAR405 is a first-in-class, selective, and ATP-competitive PI3K class III (PIK3C3) isoform Vps34 inhibitor (IC50=1.2 nM; Kd=1.5 nM) . SAR405 inhibits autophagy induced either by starvation or by mTOR inhibition. Anticancer activity[1][2].

Product Specifications

CAS Number

[1523406-39-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; PI3K

Type

Reference compound

Related Pathways

Autophagy; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/SAR405.html

Concentration

10mM

Purity

99.74

Solubility

DMSO : ≥ 27 mg/mL|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1N(C2=NC(N3[C@H](C)COCC3)=C1)CC[C@@H](C(F)(F)F)N2CC4=CC(Cl)=CN=C4

Molecular Formula

C19H21ClF3N5O2

Molecular Weight

443.85

Precautions

H302, H315, H319, H335

References & Citations

[1]Ronan B, et al. A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy. Nat Chem Biol. 2014 Dec;10 (12) :1013-9.|[2]Pasquier B. SAR405, a PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with MTOR inhibition in tumor cells. Autophagy. 2015 Apr 3;11 (4) :725-6.