ML348
ML348 (GNF-Pf-1127) is a selective and reversible acyl-protein thioesterase 1 (APT1) /lysophospholipase 1 (LYPLA1) inhibitor with an IC50 of 210 nM, and barely inhibits LYPLA2[1].
Product Specifications
CAS Number
899713-86-1
Product Name Alternative
GNF-Pf-1127
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ML348.html
Purity
99.97
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC(C(F)(F)F)=CC=C1Cl)CN2CCN(C(C3=CC=CO3)=O)CC2
Molecular Formula
C18H17ClF3N3O3
Molecular Weight
415.79
Precautions
H302, H315, H319, H335
References & Citations
[1]Adibekian A et al. Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 1 (LYPLA1) . National Center for Biotechnology Information (US) ; 2010- 2013 Apr 08.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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