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ML348

ML348 (GNF-Pf-1127) is a selective and reversible acyl-protein thioesterase 1 (APT1) /lysophospholipase 1 (LYPLA1) inhibitor with an IC50 of 210 nM, and barely inhibits LYPLA2[1].

Product Specifications

CAS Number

899713-86-1

Product Name Alternative

GNF-Pf-1127

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Phospholipase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ML348.html

Purity

99.97

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC(C(F)(F)F)=CC=C1Cl)CN2CCN(C(C3=CC=CO3)=O)CC2

Molecular Formula

C18H17ClF3N3O3

Molecular Weight

415.79

Precautions

H302, H315, H319, H335

References & Citations

[1]Adibekian A et al. Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 1 (LYPLA1) . National Center for Biotechnology Information (US) ; 2010- 2013 Apr 08.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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