ML348
ML348 (GNF-Pf-1127) is a selective and reversible acyl-protein thioesterase 1 (APT1) /lysophospholipase 1 (LYPLA1) inhibitor with an IC50 of 210 nM, and barely inhibits LYPLA2[1].
Product Specifications
CAS Number
[899713-86-1]
Product Name Alternative
GNF-Pf-1127
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ML348.html
Purity
99.97
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC(C(F)(F)F)=CC=C1Cl)CN2CCN(C(C3=CC=CO3)=O)CC2
Molecular Formula
C18H17ClF3N3O3
Molecular Weight
415.79
Precautions
H302, H315, H319, H335
References & Citations
[1]Adibekian A et al. Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 1 (LYPLA1) . National Center for Biotechnology Information (US) ; 2010- 2013 Apr 08.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
GTR15299179 1 Vial
Lentiviral mouse Usp33 shRNA (UAS) - Lentiviral mouse Usp33 shRNA (UAS, iRFP) plasmid
Ask
View Details ![Human Monoclonal Tie-2 Antibody (Regeneron patent anti-TIE-2) [DyLight 680]](https://cdn.genprice.uk/genprice/uk/genprice2.webp)
NBP3-27984FR 0.1 mL
Human Monoclonal Tie-2 Antibody (Regeneron patent anti-TIE-2) [DyLight 680]
Ask
View Details 