Nalidixic Acid-d5
Product Specifications
UNSPSC Description
Nalidixic Acid-d5 is the deuterium labeled Nalidixic acid. Nalidixic acid, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria[1].
Target Antigen
Antibiotic; Bacterial; Isotope-Labeled Compounds; Topoisomerase
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection;Cell Cycle/DNA Damage;Others
Applications
COVID-19-anti-virus
Field of Research
Infection
Solubility
10 mM in DMSO
Smiles
C(C([2H])([2H])[2H])(N1C=2C(C(=O)C(C(O)=O)=C1)=CC=C(C)N2)([2H])[2H]
Molecular Weight
237.27
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]antibiotic, DNA gyrase, susceptible bacteria, Escherichia coli, Klebsiella pneuiiioniae, Aerobacter aeroyenes, Proteus spp, Salmonella spp.|[3]Anna Fàbrega, et al. Mechanism of Action of and Resistance to Quinolones. Microb Biotechnol
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
CAS Number
1189467-36-4
Available Sizes
Curated Selection
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