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Nalidixic Acid-d5

Nalidixic Acid-d5 is the deuterium labeled Nalidixic acid. Nalidixic acid, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria[1].

Product Specifications

CAS Number

[1189467-36-4]

UNSPSC

12352005

Hazard Statement

H302-H317-H334

Target

Antibiotic; Bacterial; Isotope-Labeled Compounds; Topoisomerase

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Others

Applications

COVID-19-anti-virus

Field of Research

Infection

Solubility

10 mM in DMSO

Smiles

C(C([2H])([2H])[2H])(N1C=2C(C(=O)C(C(O)=O)=C1)=CC=C(C)N2)([2H])[2H]

Molecular Formula

C12H7D5N2O3

Molecular Weight

237.27

Precautions

P261-P264-P270-P272-P280-P284-P302+P352-P304+P340-P330-P362+P364-P501

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]antibiotic, DNA gyrase, susceptible bacteria, Escherichia coli, Klebsiella pneuiiioniae, Aerobacter aeroyenes, Proteus spp, Salmonella spp.|[3]Anna Fàbrega, et al. Mechanism of Action of and Resistance to Quinolones. Microb Biotechnol

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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