A-908292

A-908292 is a potent and selective acetyl-CoA carboxylase 2 (ACC2) inhibitor, with an IC50 of 23 nM for human ACC2. A-908292 can be used for the research of fatty acid metabolism[1][2]. A-908292 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[903886-95-3]

UNSPSC

12352005

Target

Acetyl-CoA Carboxylase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/a-908292.html

Purity

99.88

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

COC(N[C@@H](C)C#CC1=CN=C(S1)OC2=CC=C(C=C2)OC(C)C)=O

Molecular Formula

C18H20N2O4S

Molecular Weight

360.43

References & Citations

[1]Nishiura Y, et, al. Discovery of a novel olefin derivative as a highly potent and selective acetyl-CoA carboxylase 2 inhibitor with in vivo efficacy. Bioorg Med Chem Lett. 2018 Aug 1;28 (14) :2498-2503. |[2]Waring JF, et, al. Gene expression analysis in rats treated with experimental acetyl-coenzyme A carboxylase inhibitors suggests interactions with the peroxisome proliferator-activated receptor alpha pathway. J Pharmacol Exp Ther. 2008 Feb;324 (2) :507-16.|[3]Takagi H, et, al. A Novel Acetyl-CoA Carboxylase 2 Selective Inhibitor Improves Whole-Body Insulin Resistance and Hyperglycemia in Diabetic Mice through Target-Dependent Pathways. J Pharmacol Exp Ther. 2020 Mar;372 (3) :256-263.