BI2536-PEG2-Halo
BI2536-PEG2-Halo is a bifunctional molecule containing a ligand for Halo tag and a Polo-like kinase 1 (PLK1) inhibitor BI-2536. BI2536-PEG2-Halo inhibits the proliferation of 293T cells with Halo-p53R273H (FL) -mCherry tag (IC50=23 nM), exhibits selective toxicity against p53 mutant cancer cells[1].
Product Specifications
UNSPSC
12352005
Target
Polo-like Kinase (PLK)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bi2536-peg2-halo.html
Purity
99.44
Smiles
O=C(NCCOCCOCCC(NCCOCCOCCCCCCCl)=O)C1=CC=C(NC(N=C2N(C3CCCC3)[C@@H]4CC)=NC=C2N(C)C4=O)C(OC)=C1
Molecular Formula
C39H60ClN7O8
Molecular Weight
790.39
References & Citations
[1]Sadagopan A, et al. p53 protein abundance is a therapeutic window across TP53 mutant cancers and is targetable with proximity inducing small molecules[J]. bioRxiv, 2024: 2024.07. 27.605429.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC040158-500 1x 500 µL
Cytokeratin 17 (E3), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC040994-100 1x 100 µL
TNF alpha (J2D10), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC472343-100 1x 100 µL
CD9 (TSPAN29) (Motility-Related Protein-1) (CD9/2343), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC041091-500 1x 500 µL
PS2 (TFF1/1091), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details