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ICAM-1-IN-1

ICAM-1-IN-1 is a potent and selective inhibitor of E-selectin and ICAM-1 with IC50 values of 7 and 5 nM, respectively.

Product Specifications

CAS Number

251994-14-6

UNSPSC

12352005

Target

Integrin

Type

Reference compound

Related Pathways

Cytoskeleton

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Thieno[2,3-c]pyridine-2-carboxamide,_4-_4-bromophenoxy_-N-methyl-.html

Purity

99.73

Solubility

DMSO : ≥ 135 mg/mL

Smiles

O=C(C(S1)=CC2=C1C=NC=C2OC3=CC=C(Br)C=C3)NC

Molecular Formula

C15H11BrN2O2S

Molecular Weight

363.23

References & Citations

[1]Zhu GD, et al. Selective inhibition of ICAM-1 and E-selectin expression in human endothelial cells. 2. Arylmodifications of 4- (aryloxy) thieno[2,3-c]pyridines with fine-tuning at C-2 carbamides. J Med Chem. 2001 Oct 11;44 (21) :3469-87.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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