GWP-042
GWP-042 is a potent inhibitor of mycobacterial alanine dehydrogenase (Ald) Rv2780, with the IC50 of 0.21 μM. GWP-042 has antimicrobial activity against M. tuberculosis infection in vivo[1].
Product Specifications
CAS Number
1645486-93-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/gwp-042.html
Purity
99.52
Solubility
H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C([C@@H]1CCCO1)NC2=NN=C(N2)CC3=CC(F)=CC=C3
Molecular Formula
C14H15FN4O2
Molecular Weight
290.30
Precautions
H302, H315, H319, H335
References & Citations
[1]Cheng Peng, et al. Mycobacterium tuberculosis suppresses host antimicrobial peptides by dehydrogenating L-alanine. Nat Commun. 2024 May 17;15 (1) :4216.c
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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