PGP-4008

PGP-4008 is a specific P-glycoprotein (Pgp) inhibitor. PGP-4008 inhibits tumor growth in a murine syngeneic Pgp-mediated multiple agent resistance (MDR) solid tumor model when given in combination with Doxorubicin[1].

Product Specifications

CAS Number

[365565-02-2]

UNSPSC

12352005

Target

P-glycoprotein

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pgp-4008.html

Purity

99.26

Solubility

DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(CC1=CC=CC=C1)NC2=C3C(N(CC3)CC4=CC=CC=C4)=NC5=CC=CC=C25

Molecular Formula

C26H23N3O

Molecular Weight

393.48

References & Citations

[1]Brian D Lee, et al. Synthesis and evaluation of dihydropyrroloquinolines that selectively antagonize P-glycoprotein. J Med Chem. 2004 Mar 11;47 (6) :1413-22.