Bruceine A

Bruceine A (Dihydrobrusatol) is a natural quassinoid. Bruceine A is an inhibitor of parasites, NF-κB, and PFKFB4 (Kd: 44 nM) . Bruceine A is an activator of P38α MAPK. Bruceine A has antiparasitic activity. Bruceine A has antitumor activity and inhibits cancer cell migration. Bruceine A blocks the cell cycle and induces apoptosis. Bruceine A can be used in parasites, pancreatic cancer, and breast cancer research[1][2][3][4][5].

Product Specifications

CAS Number

[25514-31-2]

Product Name Alternative

Dihydrobrusatol; NSC310616

UNSPSC

12352005

Target

Apoptosis; NF-κB; p38 MAPK; Parasite; Phosphatase

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/Bruceine-A.html

Purity

99.89

Solubility

DMSO : ≥ 25 mg/mL

Smiles

O=C([C@@]1([C@H]([C@H](O)[C@]2([H])[C@]3(C4)C)O)[C@@]([C@H](C5=O)OC(CC(C)C)=O)([H])[C@@]2([C@@](O5)([H])C[C@@]3([H])C(C)=C(O)C4=O)CO1)OC

Molecular Formula

C26H34O11

Molecular Weight

522.54

References & Citations

[1]Zhang P, et al. Bruceine A induces cell growth inhibition and apoptosis through PFKFB4/GSK3β signaling in pancreatic cancer. Pharmacol Res. 2021 Jul;169:105658.|[2]Li X, et al. Bruceine A: Suppressing metastasis via MEK/ERK pathway and invoking mitochondrial apoptosis in triple-negative breast cancer. Biomed Pharmacother. 2023 Dec;168:115784.|[3]Bawm S, et al. In vitro antitrypanosomal activities of quassinoid compounds from the fruits of a medicinal plant, Brucea javanica. Vet Parasitol. 2008 Dec 20;158 (4) :288-94.|[4]Kim JA, et al. NF-kappaB inhibitors from Brucea javanica exhibiting intracellular effects on reactive oxygen species. Anticancer Res. 2010 Sep;30 (9) :3295-300.|[5]Lu C, et al. A novel P38α MAPK activator Bruceine A exhibits potent anti-pancreatic cancer activity. Comput Struct Biotechnol J. 2021 Jun 6;19:3437-3450.