TRPV4-IN-5

TRPV4-IN-5 (Compound 1f) is a potent TRPV4 inhibitor (IC50 = 0.46 μM) . TRPV4-IN-5 significantly alleviates the symptoms of acute lung injury induced by lipopolysaccharide (HY-D1056) in mice[1].

Product Specifications

CAS Number

[3046390-54-6]

UNSPSC

12352005

Target

TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/trpv4-in-5.html

Purity

98.77

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=C(S(=O)(N2CCN(C(C)C)CC2)=O)C=C1)C3=C(Cl)C=C(Cl)C=C3Cl

Molecular Formula

C20H22Cl3N3O3S

Molecular Weight

490.83

References & Citations

[1]Wang M, et al. Exploration and structure-activity relationship research of benzenesulfonamide derivatives as potent TRPV4 inhibitors for treating acute lung injury. Bioorg Chem. 2024 Jun;147:107396.