Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

CP-640186 (hydrochloride)

CP-640186 hydrochloride is an orally active and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA. CP-640186 hydrochloride can also stimulate muscle fatty acid oxidation[1][2].

Product Specifications

CAS Number

[591778-70-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Acetyl-CoA Carboxylase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/CP-640186-hydrochloride.html

Purity

99.65

Solubility

DMSO : ≥ 48 mg/mL|H2O : 50 mg/mL (ultrasonic)

Smiles

O=C([C@H]1CN(C2CCN(C(C3=C(C=CC=C4)C4=CC5=C3C=CC=C5)=O)CC2)CCC1)N6CCOCC6.Cl

Molecular Formula

C30H36ClN3O3

Molecular Weight

522.08

Precautions

H302, H315, H319, H335

References & Citations

[1]Harwood HJ Jr, et al. Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals. J Biol Chem. 2003 Sep 26;278 (39) :37099-111.|[2]Yamashita T, et al. Design, synthesis, and structure-activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors. Bioorg Med Chem Lett. 2011 Nov 1;21 (21) :6314-8.|[3]Daniel Hess, et al. Inhibition of stearoylCoA desaturase activity blocks cell cycle progression and induces programmed cell death in lung cancer cells. PLoS One. 2010 Jun 30;5 (6) :e11394.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Citation 01

J Exp Med. 2021 Dec 6;218 (12) :e20210639.|Am J Transl Res. 2019 Nov 15;11 (11) :7104-7114.|bioRxiv. 2024 May 25.|bioRxiv. 2025 Aug 26:2025.08.21.671640.|Cell Death Dis. 2025 Oct 7;16 (1) :715.|Department of Microbiology & Immunology. Seoul National University Graduate School. 2015 Aug. |Front Oncol. 2021 Apr 22:11:665763.|Front Oncol. 2021 Apr 6.|Nat Commun. 2024 Oct 21;15 (1) :9062.|Nutrients. 2021 May 21;13 (6) :1740.|Viruses. 2019 Dec 10;11 (12) :1145.

Available Sizes

More Discoveries

Explore Other Products

Browse additional items from our catalog

Lentiviral mouse Pxmp4 shRNA (UAS) - Lentiviral mouse Pxmp4 shRNA (UAS, RFP) (100)
GTR15301083 1 Vial

Lentiviral mouse Pxmp4 shRNA (UAS) - Lentiviral mouse Pxmp4 shRNA (UAS, RFP) (100)

Sign In for Pricing
View Details
Pgbd1 (BC089360) Mouse Tagged ORF Clone Lentiviral Particle
MR205581L3V 200 µL

Pgbd1 (BC089360) Mouse Tagged ORF Clone Lentiviral Particle

Sign In for Pricing
View Details
V1ra8 Protein Vector (Mouse) (pPB-N-His)
PV244791 500 ng

V1ra8 Protein Vector (Mouse) (pPB-N-His)

Sign In for Pricing
View Details
Rat Calcitonin (CT) ELISA Kit
EIA05529r 1 Kit

Rat Calcitonin (CT) ELISA Kit

Sign In for Pricing
View Details
Mdc1 sgRNA CRISPR Lentivector set (Rat)
K7478601 3x 1.0 µg

Mdc1 sgRNA CRISPR Lentivector set (Rat)

Sign In for Pricing
View Details
bisBenzimide H 33342
2179-25 25 mg

bisBenzimide H 33342

Sign In for Pricing
View Details