Bimolane
Bimolane (AT-1727), a human topoisomerase II inhibitor, can be used as an anti-neoplastic agent and for the research of psoriasis. Bimolane shows leukemogenic activity and induces multiple types of chromosomal aberrations in human lymphocytes[1][2].
Product Specifications
CAS Number
74550-97-3
Product Name Alternative
AT-1727
UNSPSC
12352005
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bimolane.html
Concentration
10mM
Solubility
10 mM in DMSO
Smiles
O=C(CN(CCN(C1)CC(N(CN2CCOCC2)C1=O)=O)C3)N(CN4CCOCC4)C3=O
Molecular Formula
C20H32N6O6
Molecular Weight
452.50
References & Citations
[1]Frantz CE, et, al. Bimolane: in vitro inhibitor of human topoisomerase II. Cancer Lett. 1997 Dec 9;120 (2) :135-40.|[2]Roy SK, et, al. Bimolane induces multiple types of chromosomal aberrations in human lymphocytes in vitro. Mutat Res. 2011 Dec 24;726 (2) :181-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo II
Available Sizes
Frequently Asked Questions
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