Bimolane

Bimolane (AT-1727), a human topoisomerase II inhibitor, can be used as an anti-neoplastic agent and for the research of psoriasis. Bimolane shows leukemogenic activity and induces multiple types of chromosomal aberrations in human lymphocytes[1][2].

Product Specifications

CAS Number

[74550-97-3]

Product Name Alternative

AT-1727

UNSPSC

12352005

Target

Topoisomerase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bimolane.html

Concentration

10mM

Solubility

10 mM in DMSO

Smiles

O=C(CN(CCN(C1)CC(N(CN2CCOCC2)C1=O)=O)C3)N(CN4CCOCC4)C3=O

Molecular Formula

C20H32N6O6

Molecular Weight

452.50

References & Citations

[1]Frantz CE, et, al. Bimolane: in vitro inhibitor of human topoisomerase II. Cancer Lett. 1997 Dec 9;120 (2) :135-40.|[2]Roy SK, et, al. Bimolane induces multiple types of chromosomal aberrations in human lymphocytes in vitro. Mutat Res. 2011 Dec 24;726 (2) :181-7.