ODQ

ODQ is a potent and selective soluble guanylyl cyclase (sGC, nitric oxide-activated enzyme) inhibitor. ODQ enhances the pro-apoptotic effects of Cisplatin in human mesothelioma cells[1].

Product Specifications

CAS Number

[41443-28-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Guanylate Cyclase

Type

Reference compound

Related Pathways

Apoptosis; GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/odq.html

Purity

99.75

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1ON=C2N1C3=C(C=CC=C3)N=C2

Molecular Formula

C9H5N3O2

Molecular Weight

187.16

Precautions

H302, H315, H319, H335

References & Citations

[1]Ronald Fiscus, et al. ODQ, an inhibitor of soluble guanylyl cyclase (nitric oxide-activated enzyme), enhances the pro-apoptotic effects of cisplatin in human mesothelioma cells. Cancer Res May 1 2007 (67) (9 Supplement) LB-43.|[2]Zacharowski K, et al. The selective guanylate cyclase inhibitor ODQ reduces multiple organ injury in rodent models of Gram-positive and Gram-negative shock. Crit Care Med. 2001;29 (8) :1599-1608.