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DL-Mevalonolactone-d7

DL-Mevalonolactone-d7 is the deuterium labeled DL-Mevalonolactone. DL-Mevalonolactone ((±) -Mevalonolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential (?Ψm), NAD (P) H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling[1][2].

Product Specifications

CAS Number

347840-19-1

Product Name Alternative

(±) -Mevalonolactone-d7; Mevalolactone-d7

UNSPSC

12352005

Target

Endogenous Metabolite

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Purity

99.27

Solubility

10 mM in DMSO|DMSO : 100mg/mL (ultrasonic) |H2O : 50mg/mL (ultrasonic)

Smiles

OC1(CC(OC([2H])([2H])C1([2H])[2H])=O)C([2H])([2H])[2H]

Molecular Formula

C6H3D7O3

Molecular Weight

137.18

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Domingos SR, et al. On the structural intricacies of a metabolic precursor: Direct spectroscopic detection of water-induced conformational reshaping of mevalonolactone. J Chem Phys. 2017 Sep 28;147 (12) :124310.|[3]Cecatto C, et al. Mevalonolactone disrupts mitochondrial functions and induces permeability transition pore opening in rat brain mitochondria: Implications for the pathogenesis of mevalonic aciduria. Neurochem Int. 2017 Sep;108:133-145.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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