NVS-PAK1-1
NVS-PAK1-1, a chemical probe, is a potent and selective allosteric PAK1 inhibitor with an IC50 of 5 nM[1].
Product Specifications
CAS Number
[1783816-74-9]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
PAK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/NVS-PAK1-1.html
Purity
99.85
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC1=CC2=C(C=C1)N(CC(F)F)C3=C(C=C(Cl)C=C3)C(N[C@H]4CCN(C(NC(C)C)=O)C4)=N2
Molecular Formula
C23H25ClF3N5O
Molecular Weight
479.93
Precautions
H315, H319, H335
References & Citations
[1]Karpov AS, et al. Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor. ACS Med Chem Lett. 2015 May 22;6 (7) :776-81.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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