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MSC2504877

MSC2504877 (M2912) is a potent and orally active tankyrase inhibitor with IC50s of 0.0007, 0.0008, 0.54 µM for TNKS, TNKS2, PARP1, respectively. MSC2504877 increases the expression of AXIN2 and TNKS protein levels and decreases β-catenin levels. MSC2504877 shows anti-tumor activity[1].

Product Specifications

CAS Number

1460286-21-8

Product Name Alternative

M2912

UNSPSC

12352005

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/msc2504877.html

Concentration

10mM

Purity

99.25

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1C2=CC=C(C)N2C=C(C3=CC=C(C(C)(O)C)C=C3)N1

Molecular Formula

C17H18N2O2

Molecular Weight

282.34

References & Citations

[1]Menon M, et al. A novel tankyrase inhibitor, MSC2504877, enhances the effects of clinical CDK4/6 inhibitors. Sci Rep. 2019 Jan 17;9 (1) :201.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PARP1

Available Sizes

Frequently Asked Questions

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