NFAT Inhibitor-2
NFAT Inhibitor-2 is a potent inhibitor of calcineurin NFAT signalling. Calcineurin is a serine/threonine protein phosphatase regulated by Ca2+ and calmodulin. NFAT Inhibitor-2 has the potential for the research of inflammatory disease, an autoimmune disorder, a cardiovascular disease, a neurodegenerative disease, a disease occurring with uncontrolled cell proliferation and/or differentiation, an angiogenesis-related disease, an allergy, anaphylaxis and alopecia (extracted from patent WO2016207212A1, compound 17) [1].
Product Specifications
CAS Number
[422546-87-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Calcineurin
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/nfat-inhibitor-2.html
Purity
98.42
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C(C)C(F)=C1)C2=CC=C(F)C(S(=O)(NCC3=CC=C(OC)C=C3)=O)=C2
Molecular Formula
C22H20F2N2O4S
Molecular Weight
446.47
Precautions
H302, H315, H319, H335
References & Citations
[1]Mercè PÉREZ RIBA, et al. Therapeutic uses of non-peptide inhibitors of the calcineurin - nfat signalling pathway. Patent WO2016207212A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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