INI-43
Product Specifications
UNSPSC Description
INI-43 is an inhibitor of Kpnβ1, interfering with the nuclear localization of Kpnβ1 and known Kpnβ1 cargo proteins, NFAT, NFκB, AP-1, and NFY. INI-43 can inhibit the proliferation of cancer cells, cause G2-M cell cycle arrest in cancer cells, and induce the intrinsic apoptosis pathway[1][2][3].
Target Antigen
AP-1; Apoptosis
Type
Reference compound
Related Pathways
Apoptosis;Immunology/Inflammation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ini-43.html
Purity
99.92
Solubility
DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
NC1=C(C2=NC3=CC=CC=C3N=C2N1CCCN(C)C)C4=NC5=CC=CC=C5N4
Molecular Weight
385.46
References & Citations
[1]F J Stanfield, et al. The antiviral activity of caprochlorone. Proc Soc Exp Biol Med. 1967 May;125(1):297-303.|[2]Chi RA, et al. Inhibition of Kpnβ1 mediated nuclear import enhances cisplatin chemosensitivity in cervical cancer. BMC Cancer. 2021 Feb 2;21(1):106.|[3]van der Watt PJ, et al. Targeting the Nuclear Import Receptor Kpnβ1 as an Anticancer Therapeutic. Mol Cancer Ther. 2016 Apr;15(4):560-73.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-121607/INI-43-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-121607/INI-43-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
881046-01-1
Available Sizes
Curated Selection
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