OICR-9429-N-C2-NH2

OICR-9429-N-C2-NH2 is a ligand for Wd40 repeat domain protein 5 (WDR5) extracted from patent WO2019246570A1, intermediate 2. OICR-9429-N-C2-NH2 can be used in the synthesis of PROTACs[1].

Product Specifications

CAS Number

[2407457-55-8]

UNSPSC

12352005

Target

Ligands for Target Protein for PROTAC; WDR5

Type

Reference compound

Related Pathways

Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/oicr-9429-n-c2-nh2.html

Solubility

10 mM in DMSO

Smiles

CN(CC1)CCN1C(C(NC(C2=CNC(C=C2C(F)(F)F)=O)=O)=C3)=CC=C3C4=CC(CN5CCN(CCN)CC5)=CC=C4

Molecular Formula

C31H38F3N7O2

Molecular Weight

597.67

References & Citations

[1]Jin J, et, al. Wd40 repeat domain protein 5 (wdr5) degradation / disruption compounds and methods of use. WO2019246570A1.|[2]Chung CW, et, al. Structural Insights into PROTAC-Mediated Degradation of Bcl-xL. ACS Chem Biol. 2020 Sep 18;15 (9) :2316-2323.