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JAK-IN-11

Product Specifications

UNSPSC Description

JAK-IN-11 is a potent and selective JAK inhibitor extracted from patent WO2012122452A1, Compound II, has the potential for the skin disorders (such as cutaneous lupus) treatment[1]. JAK-IN-11 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Target Antigen

JAK

Type

Reference compound

Related Pathways

Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Propanamide,_N-[[5-[[5-fluoro-4-[[4-_2-propyn-1-yloxy_phenyl]amino]-2-pyrimidinyl]amino]-2-methylphenyl]sulfonyl]-.html

Purity

98.62

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

C#CCOC1=CC=C(NC2=NC(NC3=CC=C(C)C(S(=O)(NC(CC)=O)=O)=C3)=NC=C2F)C=C1

Molecular Weight

483.52

References & Citations

[1]Daniel Magilavy, et al. 2,4 substituted pyrimidinediamines for use in discoid lupus. WO2012122452A1.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, stored under nitrogen)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-U00318/JAK-IN-11-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-U00318/JAK-IN-11-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

916742-11-5

Available Sizes

Curated Selection

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