HG106
HG106 is an effective SLC7A11 inhibitor. HG106 mediates apoptosis by increasing oxidative stress and endoplasmic reticulum stress, and it has antitumor activity[1].
Product Specifications
CAS Number
[928712-10-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H318, H335
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hg106.html
Concentration
10mM
Purity
99.95
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC2=NN(C3=CC=C(OC)C=C3)N=C2C=C1)CCl
Molecular Formula
C15H13ClN4O2
Molecular Weight
316.74
Precautions
H302, H315, H318, H335
References & Citations
[1]Hu K, et al. Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma. J Clin Invest. 2020 Apr 1;130 (4) :1752-1766.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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