HG106

HG106 is an effective SLC7A11 inhibitor. HG106 mediates apoptosis by increasing oxidative stress and endoplasmic reticulum stress, and it has antitumor activity[1].

Product Specifications

CAS Number

[928712-10-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H318, H335

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hg106.html

Concentration

10mM

Purity

99.95

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC2=NN(C3=CC=C(OC)C=C3)N=C2C=C1)CCl

Molecular Formula

C15H13ClN4O2

Molecular Weight

316.74

Precautions

H302, H315, H318, H335

References & Citations

[1]Hu K, et al. Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma. J Clin Invest. 2020 Apr 1;130 (4) :1752-1766.