QO-40
QO-40, a pyrazolo[1,5-a]pyrimidine-7 (4H) -one (PPO) derivative, is a KCNQ2/KCNQ3 K+ channels activator with an EC50 of 6.94 μM. QO-40 stimulated Ca2+-activated K+ current (IK (Ca) ) with an EC50 value of 2.3 μM in pituitary GH3 lactotrophs[1][2].
Product Specifications
CAS Number
1259536-70-3
UNSPSC
12352005
Hazard Statement
H302, H315, H318, H335
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/qo-40.html
Purity
98.77
Solubility
DMSO : ≥ 125 mg/mL
Smiles
O=C1C=C(CCl)NC2=C(C3=C4C=CC=CC4=CC=C3)C(C(F)(F)F)=NN12
Molecular Formula
C18H11ClF3N3O
Molecular Weight
377.75
Precautions
H302, H315, H318, H335
References & Citations
[1]Jia C, et al. Activation of KCNQ2/3 potassium channels by novel pyrazolo[1,5-a]pyrimidin-7 (4H) -one derivatives. Pharmacology. 2011;87 (5-6) :297-310.|[2]Chang WT, et al. Effective Activation of BKCa Channels by QO-40 (5- (Chloromethyl) -3- (Naphthalen-1-yl) -2- (Trifluoromethyl) Pyrazolo [1,5-a]pyrimidin-7 (4H) -one), Known to Be an Opener of KCNQ2/Q3 Channels. Pharmaceuticals (Basel) . 2021 Apr 21;14 (5) :388.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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