QO-40

QO-40, a pyrazolo[1,5-a]pyrimidine-7 (4H) -one (PPO) derivative, is a KCNQ2/KCNQ3 K+ channels activator with an EC50 of 6.94 μM. QO-40 stimulated Ca2+-activated K+ current (IK (Ca) ) with an EC50 value of 2.3 μM in pituitary GH3 lactotrophs[1][2].

Product Specifications

CAS Number

[1259536-70-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H318, H335

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/qo-40.html

Purity

98.77

Solubility

DMSO : ≥ 125 mg/mL

Smiles

O=C1C=C(CCl)NC2=C(C3=C4C=CC=CC4=CC=C3)C(C(F)(F)F)=NN12

Molecular Formula

C18H11ClF3N3O

Molecular Weight

377.75

Precautions

H302, H315, H318, H335

References & Citations

[1]Jia C, et al. Activation of KCNQ2/3 potassium channels by novel pyrazolo[1,5-a]pyrimidin-7 (4H) -one derivatives. Pharmacology. 2011;87 (5-6) :297-310.|[2]Chang WT, et al. Effective Activation of BKCa Channels by QO-40 (5- (Chloromethyl) -3- (Naphthalen-1-yl) -2- (Trifluoromethyl) Pyrazolo [1,5-a]pyrimidin-7 (4H) -one), Known to Be an Opener of KCNQ2/Q3 Channels. Pharmaceuticals (Basel) . 2021 Apr 21;14 (5) :388.