Valdecoxib

Valdecoxib is a highly potent and selective inhibitor of COX-2, with IC50s of 5 nM and 140 μM for COX-2 and COX-1, respeceively. Valdecoxib can be used in the research of arthritis and pain.

Product Specifications

CAS Number

[181695-72-7]

Product Name Alternative

SC 65872

UNSPSC

12352005

Hazard Statement

H361, H373, H401, H410

Target

COX; Endogenous Metabolite

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/Valdecoxib.html

Purity

99.96

Solubility

DMSO : ≥ 34 mg/mL

Smiles

O=S(C1=CC=C(C2=C(C)ON=C2C3=CC=CC=C3)C=C1)(N)=O

Molecular Formula

C16H14N2O3S

Molecular Weight

314.37

Precautions

H361, H373, H401, H410

References & Citations

[1]Talley JJ, et al. 4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, valdecoxib: a potent and selective inhibitor of COX-2. J Med Chem. 2000 Mar 9;43 (5) :775-7.|[2]Wiktorowska-Owczarek A. The effect of valdecoxib on the production of growth factors evoked by hypoxia and bacterial lipopolysaccharide in HMEC-1 cells. Adv Clin Exp Med. 2013 Nov-Dec;22 (6) :795-800.|[3]Kumar A, et al. Protective effects of selective and non-selective cyclooxygenase inhibitors in an animal model of chronic stress. Neurosci Bull. 2010 Feb;26 (1) :17-27.