AZ8838
AZ8838 is a potent, competitive, allosteric, orally active non-peptide small molecule antagonist of PAR2 with a pKi of 6.4 for hPAR2[1].
Product Specifications
CAS Number
[2100285-41-2]
UNSPSC
12352005
Target
Protease Activated Receptor (PAR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/az8838.html
Concentration
10mM
Purity
99.30
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O[C@H](C1=NC=CN1)C2=C(C=C(C=C2)F)CCC
Molecular Formula
C13H15FN2O
Molecular Weight
234.27
References & Citations
[1]Kennedy AJ, et al. Protease-activated receptor-2 ligands reveal orthosteric and allosteric mechanisms of receptor inhibition. Commun Biol. 2020 Dec 17;3 (1) :782.|[2]Cheng RKY, Fiez-Vandal C, Schlenker O, et al. Structural insight into allosteric modulation of protease-activated receptor 2. Nature. 2017;545 (7652) :112-115.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PAR2
Available Sizes
Curated Selection
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