Diclofenac amide
Diclofenac amide is a prodrug for Diclofenac sodium. Diclofenac amide is an orally active inhibitor for COX-1/2, that inhibits the production of prostaglandins (PG) and thromboxanes (TX). Diclofenac amide exhibits anti-inflammatory efficacy in Carrageenan (HY-125474) -induced rat paw edema model without causing gastric ulcer (300 μmol/kg).
Product Specifications
CAS Number
15362-40-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
COX
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/diclofenac-amide.html
Purity
99.02
Smiles
O=C1N(C2=C(Cl)C=CC=C2Cl)C3=C(C=CC=C3)C1
Molecular Formula
C14H9Cl2NO
Molecular Weight
278.14
Precautions
H302, H315, H319, H335
References & Citations
[1]Santos JL, et al., Pharmacological evaluation and preliminary pharmacokinetics studies of a new diclofenac prodrug without gastric ulceration effect. Int J Mol Sci. 2012 Nov 19;13 (11) :15305-20.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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