Capivasertib
Product Specifications
UNSPSC Description
Capivasertib (AZD5363) is an orally active and potent pan-AKT kinase inhibitor with IC50 of 3, 7 and 7 nM for Akt1,Akt2 and Akt3, respectively.
Target Antigen
Akt; Autophagy
Type
Reference compound
Related Pathways
Autophagy;PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AZD5363.html
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C1(N)CCN(C2=C3C(NC=C3)=NC=N2)CC1)N[C@H](C4=CC=C(Cl)C=C4)CCO
Molecular Weight
428.92
References & Citations
[1]Davies BR, et al. Preclinical pharmacology of AZD5363, an inhibitor of AKT: pharmacodynamics, antitumor activity, and correlation of monotherapy activity with genetic background. Mol Cancer Ther. 2012 Apr;11(4):873-87.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-15431/Capivasertib-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-15431/Capivasertib-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
1143532-39-1
Available Sizes
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