HDAC6-IN-37

HDAC6-IN-37 (compound W5) is an inhibitor of HDAC6 and has neuroprotective effects. HDAC6-IN-37 can restore the morphology of hippocampal neurons, reduce the expression of Aβ, Tau, and p-Tau proteins in the hippocampus of AD rats, and inhibit the formation of senile plaques and neurofibrillary tangles. Thus, HDAC6-IN-37 improves the Aβ/Cu2+-induced AD model in rats, regulates oxidative stress status, and balances neurotransmitter disorders in brain tissue[1].

Product Specifications

CAS Number

[2986486-82-0]

UNSPSC

12352005

Target

HDAC

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/hdac6-in-37.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CN=C(C=C1)CN2C3=CC=CC=C3SC4=C2C=CC=C4)NO.Cl

Molecular Formula

C19H16ClN3O2S

Molecular Weight

385.87

References & Citations

[1]Liu R, et al. Study on multi-target effects of the novel HDAC6 inhibitor W5 on Aβ/Cu2+-induced Alzheimer's disease model of rats. Brain Res. 2024 Mar 3;1832:148847.