Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

SAR-020106

SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC50 of 13.3 nM for human CHK1. SAR-020106 shows excellent selectivity over CHK2. SAR-020106 significantly enhances the cell killing of Gemcitabine and SN38 by 3- to 29-fold in several colon tumor lines and in a p53-dependent fashion. SAR-020106 can enhance antitumor activity with selected anticancer agents[1][2].

Product Specifications

CAS Number

1184843-57-9

UNSPSC

12352005

Target

Checkpoint Kinase (Chk)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sar-020106.html

Concentration

10mM

Purity

98.04

Solubility

DMSO : 5 mg/mL (ultrasonic)

Smiles

N#CC1=NC=C(NC2=CC3=C(C=N2)C(Cl)=CC=C3)N=C1O[C@H](C)CN(C)C

Molecular Formula

C19H19ClN6O

Molecular Weight

382.85

References & Citations

[1]Walton MI, et al. The preclinical pharmacology and therapeutic activity of the novel CHK1 inhibitor SAR-020106. Mol Cancer Ther. 2010;9 (1) :89-100.|[2]Reader JC, et al. Structure-guided evolution of potent and selective CHK1 inhibitors through scaffold morphing. J Med Chem. 2011;54 (24) :8328-8342.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Chk1

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

rac Salsolinol Hydrochloride
TRC-S100000-500MG 500 mg

rac Salsolinol Hydrochloride

Sign In for Pricing
View Details
PACSIN3 Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI2A3]
TA502251BM 100 µL

PACSIN3 Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI2A3]

Sign In for Pricing
View Details
Histone H3 Rabbit Polyclonal Antibody
AP20240PU-N 100 µg

Histone H3 Rabbit Polyclonal Antibody

Sign In for Pricing
View Details
GHDC (NM_001142623) Human Over-expression Lysate
LY428217 100 µg

GHDC (NM_001142623) Human Over-expression Lysate

Sign In for Pricing
View Details
Erysotrin
TRC-E404380-100MG 100 mg

Erysotrin

Sign In for Pricing
View Details
Trpc6 Mouse Gene Knockout Kit (CRISPR)
KN318295BN 1 Kit

Trpc6 Mouse Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details