RGT-018
RGT-018 is a potent and orally active SOS1 inhibitor with anti-tumor effects. RGT-018 exerts anti-cancer cell proliferation activity by inhibiting KRAS activation[1].
Product Specifications
CAS Number
[2794934-49-7]
UNSPSC
12352005
Target
Ras; SOS1
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rgt-018.html
Purity
99.77
Solubility
DMSO : 20 mg/mL (ultrasonic; adjust pH to 2 with 1 M HCL)
Smiles
O=C1C(C2=CN=C(C#N)C=C2)=C3C(C(N[C@@H](C4=C(C(C(F)F)=CC=C4)F)C)=NC(C)=N3)=CN1N5CCOCC5
Molecular Formula
C27H24F3N7O2
Molecular Weight
535.52
References & Citations
[1]Fei Xiao, et al. "Discovery of RGT-018: A Potent, Selective, and Orally Bioavailable SOS1 Inhibitor for KRAS-Driven Cancers." Molecular Cancer Therapeutics (2024) : OF1-OF14.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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