HPK1-IN-43
HPK1-IN-43 (compound 9f) is a HPK1 kinase inhibitor with the IC50 value of 0.32 nM. HPK1-IN-43 inhibits the phosphorylation of the downstream protein SLP-76 and enhances the secretion of interleukin-2 (IL-2) and interferon-γ (IFN-γ) . HPK1-IN-43 can be used in cancer research[1].
Product Specifications
UNSPSC
12352005
Target
IFNAR; Interleukin Related; MAP4K
Type
Reference compound
Related Pathways
Immunology/Inflammation; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hpk1-in-43.html
Solubility
10 mM in DMSO
Smiles
O=C1N(CC2=C(C(F)(F)F)C=CC=C2)C3=NC(NC4=C(OC)C=C(CCN(C)C5)C5=C4)=NC=C3C(N)=C1
Molecular Formula
C26H25F3N6O2
Molecular Weight
510.51
References & Citations
[1]Qiu X, et al. Discovery of 5-aminopyrido[2,3-d]pyrimidin-7 (8H) -one derivatives as new hematopoietic progenitor kinase 1 (HPK1) inhibitors. Eur J Med Chem. 2024 Apr 5;269:116310.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-2; MAP4K1/HPK1
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