HPK1-IN-43

HPK1-IN-43 (compound 9f) is a HPK1 kinase inhibitor with the IC50 value of 0.32 nM. HPK1-IN-43 inhibits the phosphorylation of the downstream protein SLP-76 and enhances the secretion of interleukin-2 (IL-2) and interferon-γ (IFN-γ) . HPK1-IN-43 can be used in cancer research[1].

Product Specifications

UNSPSC

12352005

Target

IFNAR; Interleukin Related; MAP4K

Type

Reference compound

Related Pathways

Immunology/Inflammation; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hpk1-in-43.html

Solubility

10 mM in DMSO

Smiles

O=C1N(CC2=C(C(F)(F)F)C=CC=C2)C3=NC(NC4=C(OC)C=C(CCN(C)C5)C5=C4)=NC=C3C(N)=C1

Molecular Formula

C26H25F3N6O2

Molecular Weight

510.51

References & Citations

[1]Qiu X, et al. Discovery of 5-aminopyrido[2,3-d]pyrimidin-7 (8H) -one derivatives as new hematopoietic progenitor kinase 1 (HPK1) inhibitors. Eur J Med Chem. 2024 Apr 5;269:116310.