D927
D927 (DS11252927) is an orally active glucose transporter type 4 (GLUT4) translocation activator with an EC50 of 0.14 μM. D927 enhances the binding affinity of PI3Kα catalytic subunit p110α to canonical RAS proteins (KRAS4A, KRAS4B) and RRAS, RRAS2, MRAS. D927 activates the PI3Kα-AKT pathway (increasing phosphorylation of AKT, p70S6 kinase) without affecting the RAF-ERK1/2 pathway. D927 improves hyperglycemia in type 1 and type 2 diabetes mice model. D927 can be used for the study of glucose homeostasis disorders and diabetes[1][2].
Product Specifications
CAS Number
2253733-37-6
Product Name Alternative
DS11252927
UNSPSC
12352005
Target
Akt; GLUT; PI3K
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; PI3K/Akt/mTOR
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/glut4-activator-1.html
Purity
99.46
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
COCCOC1=CC=CC=C1C2=C(SC=C3)C3=C(NC4=CC=C(CC(N)=O)C=C4F)N=N2
Molecular Formula
C23H21FN4O3S
Molecular Weight
452.50
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GLUT4; PI3Kα
Available Sizes
Frequently Asked Questions
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