GSK8612
GSK8612 is a highly selective and potent Tank-binding Kinase-1 (TBK1) inhibitor, with a pIC50 of 6.8 for recombinant TBK1[1].
Product Specifications
CAS Number
[2361659-62-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
IKK
Type
Reference compound
Related Pathways
NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gsk8612.html
Purity
99.56
Solubility
DMSO : ≥ 125 mg/mL
Smiles
NS(C1=CC=C(CNC2=C(Br)C=NC(NC3=CN(CC(F)(F)F)N=C3C)=N2)C=C1)(=O)=O
Molecular Formula
C17H17BrF3N7O2S
Molecular Weight
520.33
Precautions
H302, H315, H319, H335
References & Citations
[1]Thomson DW, et al. Discovery of GSK8612, a Highly Selective and Potent TBK1 Inhibitor. ACS Med Chem Lett. 2019 Mar 11;10 (5) :780-785.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TBK1
Available Sizes
Curated Selection
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