PP121

PP121 is a multi-targeted kinase inhibitor with IC50s of 10, 60, 12, 14, 2 nM for mTOR, DNK-PK, VEGFR2, Src, PDGFR, respectively.

Product Specifications

CAS Number

[1092788-83-4]

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; mTOR; PDGFR; Src; VEGFR

Type

Reference compound

Related Pathways

Apoptosis; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/PP121.html

Purity

99.51

Solubility

DMSO : 20 mg/mL (ultrasonic)

Smiles

NC1=C2C(C3=CC4=C(N=C3)NC=C4)=NN(C2=NC=N1)C5CCCC5

Molecular Formula

C17H17N7

Molecular Weight

319.36

Precautions

H302

References & Citations

[1]Apsel B, et al. Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol, 2008, 4 (11), 691-699.|[2]Peng Y, et al. The anti-esophageal cancer cell activity by a novel tyrosine/phosphoinositide kinase inhibitor PP121. Biochem Biophys Res Commun. 2015 Sep 11;465 (1) :137-44.