What is the catalog number for PP121?

The catalog number for PP121 is HY-10372.

What sizes are available for PP121?

PP121 is available in the following size(s): 5 mg, 10 mg, 10 mM - 1 mL, 50 mg, 100 mg.

How many pack sizes does PP121 come in?

PP121 is available in 5 different pack sizes.

PP121 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures PP121?

PP121 is manufactured by QuantiMol.

What is the estimated delivery time for PP121?

Estimated delivery time for PP121 is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for PP121?

The safety data sheet for PP121 is available here: http://file.medchemexpress.com/batch_PDF/HY-10372/PP121-SDS-MedChemExpress.pdf.

PP121

PP121 is a multi-targeted kinase inhibitor with IC50s of 10, 60, 12, 14, 2 nM for mTOR, DNK-PK, VEGFR2, Src, PDGFR, respectively.

Product Specifications

CAS Number

1092788-83-4

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; mTOR; PDGFR; Src; VEGFR

Type

Reference compound

Related Pathways

Apoptosis; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/PP121.html

Purity

99.51

Solubility

DMSO : 20 mg/mL (ultrasonic)

Smiles

NC1=C2C(C3=CC4=C(N=C3)NC=C4)=NN(C2=NC=N1)C5CCCC5

Molecular Formula

C17H17N7

Molecular Weight

319.36

Precautions

H302

References & Citations

[1]Apsel B, et al. Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol, 2008, 4 (11), 691-699.|[2]Peng Y, et al. The anti-esophageal cancer cell activity by a novel tyrosine/phosphoinositide kinase inhibitor PP121. Biochem Biophys Res Commun. 2015 Sep 11;465 (1) :137-44.